
5B9 Monoclonal Antibody: Fully mimics the effects of human HIT antibodies
5B9 is a monoclonal antibody that fully mimics the effects of human Heparin Induced Thrombocytopenia (HIT) antibodies [1]:
- anti-PF4/Heparin IgG antibody with human Fc fragment,
- induces heparin- and FcϒRIIA-dependent platelet activation,
- specific to the PF4/Heparin complex with very low reactivity against PF4 alone.
5B9 clinical research on HIT functional assays covers the following objectives:
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